产品名称
PHAR3 Rabbit Polyclonal Antibody
基因名称
PHACTR3 C20orf101 SCAPIN1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/116154
Human Swissprot No.
Q96KR7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96KR7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/74189
Mouse Swissprot No.
Q8BYK5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BYK5
Rat Gene Link
https://www.uniprot.org/uniprot/362284
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6RFY2
免疫原
Synthesized peptide derived from human PHAR3 AA range: 260-310
特异性
This antibody detects endogenous levels of PHAR3 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
组织表达
Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL-60 leukemia cells.
细胞定位
Nucleus matrix. Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.
功能
induction:Down-regulated in HL-60 leukemia cells by RA, PMA and dimethyl sulfoxide.,similarity:Belongs to the phosphatase and actin regulator family.,similarity:Contains 4 RPEL repeats.,subcellular location:Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.,subunit:Binds actin and PPP1CA; thus inhibiting the protein phosphatase 1 (PP1) activity.,tissue specificity:Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U937, GOTO and HL-60 leukemia cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
