产品名称
BLMH Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/642
Human Swissprot No.
Q13867
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13867/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/104184
Mouse Swissprot No.
Q8R016
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R016
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P70645
免疫原
Synthesized peptide derived from human BLMH AA range: 170-220
特异性
This antibody detects endogenous levels of BLMH at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Cytoplasmic granule . Co-localizes with NUDT12 in the cytoplasmic granules. .
功能
catalytic activity:Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.,function:The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.,similarity:Belongs to the peptidase C1 family.,subunit:Homohexamer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
