产品名称
ABR Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/29
Human Swissprot No.
Q12979
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q12979/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/109934
Mouse Swissprot No.
Q5SSL4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5SSL4
免疫原
Synthesized peptide derived from human ABR AA range: 393-443
特异性
This antibody detects endogenous levels of ABR at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012],
组织表达
Highly enriched in the brain. Much weaker expression in heart, lung and muscle.
细胞定位
Cell projection, dendritic spine . Cell projection, axon . Cell junction, synapse .
功能
function:GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them.,similarity:Contains 1 C2 domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Highly enriched in the brain. Much weaker expression in heart, lung and muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
