产品名称
RN139 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11236
Human Swissprot No.
Q8WU17
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8WU17/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/75841
Mouse Swissprot No.
Q7TMV1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TMV1
免疫原
Synthesized peptide derived from human RN139 AA range: 10-60
特异性
This antibody detects endogenous levels of RN139 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain, liver, skeletal muscle and pancreas, and low expression in lung and kidney.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
disease:Defects in RNF139 are a cause of renal cell carcinoma (RCC) [MIM:144700]. A chromosomal aberration involving RNF139 is found in hereditary RCC. Translocation (3;8)(q14.2;q24.1) with FHIT. The result is RNF139 is found to be fused to FHIT and disrupted within the sterol-sensing domain. In contrast, the FHIT coding region is maintained and expressed. Sporadic RCC, where an acquired mutation in RNF139 results in the duplication of 12 nucleotides in the 5'-UTR, has also been identified.,domain:The RING-type zinc finger domain may be essential for ubiquitin ligase activity.,function:Potential tumor suppressor for renal cell carcinoma. Plays a role in mediating ubiquitination. May function as a signaling receptor.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with VHL.,tissue specificity:Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain, liver, skeletal muscle and pancreas, and low expression in lung and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
