产品名称
SIAT9 Rabbit Polyclonal Antibody
基因名称
ST3GAL5 SIAT9 UNQ2510/PRO5998
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8869
Human Swissprot No.
Q9UNP4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UNP4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20454
Mouse Swissprot No.
O88829
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88829
Rat Gene Link
https://www.uniprot.org/uniprot/83505
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q68G12
免疫原
Synthesized peptide derived from human SIAT9 AA range: 157-207
特异性
This antibody detects endogenous levels of SIAT9 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis. mRNA widely distributed in human brain, but slightly elevated expression was observed in the cerebral cortex, temporal lobe, and putamen.
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
功能
catalytic activity:CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.,disease:Defects in ST3GAL5 are the cause of Amish infantile epilepsy syndrome (AIES) [MIM:609056]. AIES is an autosomal recessive, infantile-onset symptomatic epilepsy associated with developmental stagnation and blindness.,function:Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).,online information:GlycoGene database,online information:ST3Gal V,PTM:N-glycosylated.,similarity:Belongs to the glycosyltransferase 29 family.,tissue specificity:Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
