产品名称
ADR2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/79602
Human Swissprot No.
Q86V24
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86V24/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/68465
Mouse Swissprot No.
Q8BQS5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BQS5
免疫原
Synthesized peptide derived from human ADR2 AA range: 62-112
特异性
This antibody detects endogenous levels of ADR2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008],
组织表达
Ubiquitous (PubMed:16044242). Highly expressed in skeletal muscle, liver and placenta (PubMed:12802337). Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung (PubMed:12802337).
细胞定位
Cell membrane ; Multi-pass membrane protein . Localized to the cell membrane and intracellular organelles. .
功能
function:Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.,online information:Adiponectin entry,similarity:Belongs to the ADIPOR family.,subcellular location:Localized to the cell membrane and intracellular organelles.,subunit:May form homo and heteromultimers.,tissue specificity:Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
