产品名称
DTX3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/196403
Human Swissprot No.
Q8N9I9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N9I9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/80904
Mouse Swissprot No.
Q80V91
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80V91
免疫原
Synthesized peptide derived from human DTX3 AA range: 87-137
特异性
This antibody detects endogenous levels of DTX3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009],
功能
function:Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.,sequence caution:Intron retention.,similarity:Belongs to the Deltex family.,similarity:Contains 1 RING-type zinc finger.,subunit:Homomultimer. May form a heteromultimer with other members of the Deltex family. Interacts with NOTCH1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
