产品名称
FBX17 Rabbit Polyclonal Antibody
基因名称
FBXO17 FBG4 FBX17 FBX26 FBXO26
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/115290
Human Swissprot No.
Q96EF6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96EF6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/50760
Mouse Swissprot No.
Q9QZM8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QZM8
Rat Gene Link
https://www.uniprot.org/uniprot/292757
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AY27
免疫原
Synthesized peptide derived from human FBX17 AA range: 61-111
特异性
This antibody detects endogenous levels of FBX17 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
组织表达
Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.
细胞定位
SCF ubiquitin ligase complex,
功能
function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 1 FBA (F-box associated) domain.,subunit:Directly interacts with SKP1A and CUL1.,tissue specificity:Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
