产品名称
MTCO2?Rabbit?Polyclonal Antibody
别名
Co2,Cytochrome c oxidase polypeptide II,Cytochrome c oxidase subunit 2,COII,COX2, COXII,MTCO2,MT-CO2
蛋白名称
Cytochrome c oxidase subunit 2 (Cytochrome c oxidase polypeptide II)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P00403
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P00403/entry
Mouse Swissprot No.
P00405
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P00405
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P00406
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
COX2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
cofactor:Copper A.,disease:Defects in MT-CO2 are a cause of cytochrome c oxidase deficiency (COX deficiency) [MIM:220110]; also called mitochondrial complex IV deficiency. COX deficiency is a clinically heterogeneous disorder. The clinical features are ranging from isolated myopathy to severe multisystem disease, with onset from infancy to adulthood.,disease:Defects in MT-CO2 are associated with tumor formation.,function:Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.,similarity:Belongs to the cytochrome c oxidase subunit 2 family.,
组织表达
Blood,Bone fossil,Bones,Breast cancer,Distant normal tissue,Endometrial ade
细胞定位
Mitochondrion inner membrane ; Multi-pass membrane protein .
信号通路
Oxidative phosphorylation;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;
功能
cofactor:Copper A.,disease:Defects in MT-CO2 are a cause of cytochrome c oxidase deficiency (COX deficiency) [MIM:220110]; also called mitochondrial complex IV deficiency. COX deficiency is a clinically heterogeneous disorder. The clinical features are ranging from isolated myopathy to severe multisystem disease, with onset from infancy to adulthood.,disease:Defects in MT-CO2 are associated with tumor formation.,function:Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.,similarity:Belongs to the cytochrome c oxidase subunit 2 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
