产品名称
PIGM Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/93183
Human Swissprot No.
Q9H3S5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H3S5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67556
Mouse Swissprot No.
Q8C2R7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C2R7
Rat Gene Link
https://www.uniprot.org/uniprot/79112
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EQY6
免疫原
Synthesized peptide derived from human PIGM AA range: 147-197
特异性
This antibody detects endogenous levels of PIGM at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008],
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
disease:Defects in PIGM are the cause of glycosylphosphatidylinositol deficiency (GPID) [MIM:610293]. GPID is an autosomal recessive trait that results in a propensity to venous thrombosis and seizures. Deficiency is due to a point mutation in the regulatory sequences of PIGM that disrupts binding of the transcription factor SP1 to its cognate promoter motif, leading to a strong reduction of expression.,function:Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.,pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.,similarity:Belongs to the PIGM family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
