产品名称
CXXC4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/80319
Human Swissprot No.
Q9H2H0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H2H0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/319478
Mouse Swissprot No.
Q6NXI8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6NXI8
Rat Gene Link
https://www.uniprot.org/uniprot/83824
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EQC9
免疫原
Synthesized peptide derived from human CXXC4 AA range: 15-65
特异性
This antibody detects endogenous levels of CXXC4 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
功能
function:Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.,similarity:Contains 1 CXXC-type zinc finger.,subunit:Interacts with the PDZ domain of DVL1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
