产品名称
ZFP57 Rabbit Polyclonal Antibody
基因名称
ZFP57 C6orf40 ZNF698
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/346171
Human Swissprot No.
Q9NU63
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NU63/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22715
Mouse Swissprot No.
Q8C6P8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C6P8
Rat Gene Link
https://www.uniprot.org/uniprot/361783
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/A0JPK3
免疫原
Synthesized peptide derived from human ZFP57 AA range: 373-423
特异性
This antibody detects endogenous levels of ZFP57 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009],
细胞定位
Nucleus . Binds various differentially methylated regions (DMR). .
功能
disease:Defects in ZFP57 are the cause of transient neonatal diabetes mellitus type 1 (TNDM1) [MIM:601410]. Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. The major cause of TNDM1 is aberrant expression of imprinted genes at chromosome 6q24, associated in 20% of cases with DNA hypomethylation at the transient neonatal diabetes differentially methylated region (DMR), which lies within the imprinted promoter of the PLAGL1 gene. Over 50% of individuals with transient neonatal diabetes and hypomethylation at 6q24 also show mosaic DNA hypomethylation at other imprinted loci throughout the genome and a range of additional clinical features.,domain:The KRAB domain is required for function as transcriptional repressor.,function:Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family. ZFP57 subfamily.,similarity:Contains 1 KRAB domain.,similarity:Contains 7 C2H2-type zinc fingers.,subcellular location:Binds various differentially methylated regions (DMR), including the Snrpn DMR.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
