产品名称
SELH Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/280636
Human Swissprot No.
Q8IZQ5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IZQ5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72657
Mouse Swissprot No.
Q3UQA7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UQA7
免疫原
Synthesized peptide derived from human SELH AA range: 58-108
特异性
This antibody detects endogenous levels of SELH at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016],
功能
function:May be involved in a redox-related process .,similarity:Belongs to the SelWTH family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
