产品名称
PNCB Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/93100
Human Swissprot No.
Q6XQN6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6XQN6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/223646
Mouse Swissprot No.
Q8CC86
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CC86
Rat Gene Link
https://www.uniprot.org/uniprot/315085
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6XQN1
免疫原
Synthesized peptide derived from human PNCB AA range: 134-184
特异性
This antibody detects endogenous levels of PNCB at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008],
细胞定位
Cytoplasm, cytosol .
功能
catalytic activity:Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.,function:Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.,pathway:Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate ribonucleotide from nicotinate: step 1/1.,similarity:Belongs to the NAPRTase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
