产品名称
CYBR1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/79901
Human Swissprot No.
Q53TN4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q53TN4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/73649
Mouse Swissprot No.
Q925G2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q925G2
Rat Gene Link
https://www.uniprot.org/uniprot/295669
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5RKJ2
免疫原
Synthesized peptide derived from human CYBR1 AA range: 41-91
特异性
This antibody detects endogenous levels of CYBR1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008],
组织表达
Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.
细胞定位
Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Localized at the brush border of duodenal cells. .
功能
cofactor:Binds 2 heme groups non-covalently.,disease:Defects in CYBRD1 may be a cause of primary hereditary hemochromatosis (HFE). HFE is an iron-loading disorder characterized by iron accumulation in parenchymal cells. Iron accumulation usually results in tissue damage and causes cirrhosis of the liver, diabetes mellitus, arthropathy, cardiomyopathy, endocrine abnormalities and an increased risk of hepatocellular carcinoma.,function:Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.,induction:By iron deficiency (at protein level).,similarity:Contains 1 cytochrome b561 domain.,tissue specificity:Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
