产品名称
RIMB1 Rabbit Polyclonal Antibody
基因名称
BZRAP1 KIAA0612 RBP1 RIMBP1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9256
Human Swissprot No.
O95153
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95153/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/207777
Mouse Swissprot No.
Q7TNF8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TNF8
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JIR0
免疫原
Synthesized peptide derived from human RIMB1 AA range: 24-74
特异性
This antibody detects endogenous levels of RIMB1 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
组织表达
Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level is also observed in fetal tissues like brain, heart, kidney and thymus.
细胞定位
Cytoplasm . Mitochondrion . Preferentially expressed in the mitochondria in the presence of TSPO.
功能
caution:PubMed:9915832 demonstrated interaction with BZRP but later PubMed:12435798 demonstrated in the rat ortholog that is not associated with BZRP in the brain.,domain:The SH3 and proline-rich domain is required for the interaction with BZRP and the second SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2.,similarity:Belongs to the RIMBP family.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 3 SH3 domains.,subcellular location:Preferentially expressed in the mitochondria in the presence of BZRP.,subunit:Interacts with RIMS1 and RIMS2 (By similarity). Interacts with BZRP.,tissue specificity:Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level is also observed in fetal tissues like brain, heart, kidney and thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
