产品名称
DOC2B Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8447
Human Swissprot No.
Q14184
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14184/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13447
Mouse Swissprot No.
P70169
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70169
Rat Gene Link
https://www.uniprot.org/uniprot/81820
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P70610
免疫原
Synthesized peptide derived from human DOC2B AA range: 332-382
特异性
This antibody detects endogenous levels of DOC2B at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level).
细胞定位
Cytoplasm. Cytoplasmic granule . Cell membrane ; Peripheral membrane protein . Translocates to the plasma membrane in a calcium-dependent manner. .
功能
domain:C2 domain 1 is involved in binding calcium and phospholipids.,function:May be involved in constitutive membrane trafficking including dynein-dependent intracellular vesicle transport. In vitro, binds calcium and phospholipids.,similarity:Contains 2 C2 domains.,subunit:Interacts with cytoplasmic dynein light chain TCTEL1/TCTEX1.,tissue specificity:Widely expressed with highest levels in brain and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
