产品名称
SYNJ2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8871
Human Swissprot No.
O15056
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15056/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20975
Mouse Swissprot No.
Q9D2G5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D2G5
Rat Gene Link
https://www.uniprot.org/uniprot/84018
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O55207
免疫原
Synthesized peptide derived from human SYNJ2 AA range: 145-195
特异性
This antibody detects endogenous levels of SYNJ2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
细胞定位
Cytoplasm . Cell membrane . Membrane raft . Cell junction, synapse, presynapse . Cytoplasm, cytoskeleton . Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340). .
功能
alternative products:Additional isoforms seem to exist,catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.,domain:The C-terminal proline-rich region of isoform 2B2 mediates binding to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.,function:Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.,similarity:Belongs to the synaptojanin family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 1 SAC domain.,similarity:In the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family.,subcellular location:Predominantly associated with the particulate fractions.,subunit:Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
