产品名称
UBP18 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11274
Human Swissprot No.
Q9UMW8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UMW8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/24110
Mouse Swissprot No.
Q9WTV6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTV6
免疫原
Synthesized peptide derived from human UBP18 AA range: 66-116
特异性
This antibody detects endogenous levels of UBP18 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011],
细胞定位
[Isoform 1]: Cytoplasm .; [Isoform 2]: Nucleus . Cytoplasm .
功能
catalytic activity:ISG15 C-terminal thiolester + H(2)O = ISG15 + a thiol.,catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.,similarity:Belongs to the peptidase C19 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
