产品名称
CBX4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8535
Human Swissprot No.
O00257
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00257/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12418
Mouse Swissprot No.
O55187
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O55187
免疫原
Synthesized peptide derived from human CBX4 AA range: 196-246
特异性
This antibody detects endogenous levels of CBX4 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
细胞定位
Nucleus . Nucleus speckle . Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235). .
功能
function:E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.,pathway:Protein modification; protein sumoylation.,PTM:Phosphorylated on Thr-495 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-492.,similarity:Contains 1 chromo domain.,subunit:Interacts with histone H3-K9Me3 (By similarity). Component of chromatin-associated class II PcG repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Interacts with SUV39H1 and HIPK2.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
