产品名称
RNF4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6047
Human Swissprot No.
P78317
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P78317/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19822
Mouse Swissprot No.
Q9QZS2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QZS2
Rat Gene Link
https://www.uniprot.org/uniprot/29274
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88846
免疫原
Synthesized peptide derived from human RNF4 AA range: 71-121
特异性
This antibody detects endogenous levels of RNF4 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010],
组织表达
Widely expressed at low levels in many tissues; highly expressed in testis.
细胞定位
Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm.
功能
function:Enhances steroid receptor-mediated transcriptional activation as well as activating basal transcription.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with GSCL, Androgen receptor, TCF20, TBP and PATZ1.,tissue specificity:Widely expressed at low levels in many tissues; highly expressed in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
