产品名称
WDR62 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/284403
Human Swissprot No.
O43379
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43379/entry
Mouse Swissprot No.
Q3U3T8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3U3T8
免疫原
Synthesized peptide derived from human WDR62 AA range: 984-1034
特异性
This antibody detects endogenous levels of WDR62 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated with microencephaly, cortical malformations, and mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011],
组织表达
Present in fetal brain, enriched within the ventricular and subventricular zone (at protein level). In the embryonic brain it is expressed in mitotic neural precursor cells.
细胞定位
Nucleus . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Shows cell cycle-dependent localization. Accumulates to the spindle pole during mitosis. Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. .
功能
similarity:Contains 15 WD repeats.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
