产品名称
ELMO3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/79767
Human Swissprot No.
Q96BJ8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96BJ8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/234683
Mouse Swissprot No.
Q8BYZ7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BYZ7
Rat Gene Link
https://www.uniprot.org/uniprot/291962
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q499U2
免疫原
Synthesized peptide derived from human ELMO3 AA range: 336-386
特异性
This antibody detects endogenous levels of ELMO3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008],
功能
function:Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.,similarity:Contains 1 ELMO domain.,similarity:Contains 1 PH domain.,subunit:Probably interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
