产品名称
UBP20 Rabbit Polyclonal Antibody
基因名称
USP20 KIAA1003 LSFR3A VDU2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10868
Human Swissprot No.
Q9Y2K6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y2K6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/74270
Mouse Swissprot No.
Q8C6M1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C6M1
免疫原
Synthesized peptide derived from human UBP20 AA range: 104-154
特异性
This antibody detects endogenous levels of UBP20 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013],
细胞定位
Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 UBP-type zinc finger.,similarity:Contains 2 DUSP domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
