产品名称
NAL12 Rabbit Polyclonal Antibody
基因名称
NLRP12 NALP12 PYPAF7 RNO
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/91662
Human Swissprot No.
P59046
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P59046/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/378425
Mouse Swissprot No.
E9Q5R7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/E9Q5R7
免疫原
Synthesized peptide derived from human NAL12 AA range: 456-506
特异性
This antibody detects endogenous levels of NAL12 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013],
组织表达
Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
功能
disease:Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.,function:May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.,induction:By nitric oxide and DMSO in HL60 cells, an acute myeloid leukemia cell line.,similarity:Belongs to the NLRP family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Binds to ASC with its DAPIN domain.,tissue specificity:Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
