产品名称
LOX15 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/246
Human Swissprot No.
P16050
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P16050/entry
免疫原
Synthesized peptide derived from human LOX15 AA range: 156-206
特异性
This antibody detects endogenous levels of LOX15 at Human
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
组织表达
Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.
细胞定位
Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein . Lipid droplet . Predominantly cytosolic; becomes enriched at membranes upon calcium binding (By similarity). Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells (By similarity). .
功能
catalytic activity:Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.,cofactor:Binds 1 iron ion per subunit.,function:Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid.,pathway:Lipid metabolism; leukotriene D4 biosynthesis.,similarity:Belongs to the lipoxygenase family.,similarity:Contains 1 lipoxygenase domain.,similarity:Contains 1 PLAT domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
