产品名称
CD320 Rabbit Polyclonal Antibody
基因名称
CD320 8D6A UNQ198/PRO224
蛋白名称
CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NPF0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NPF0/entry
Mouse Swissprot No.
Q9Z1P5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1P5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5HZW5
免疫原
Synthesized peptide derived from human protein . at AA range: 100-180
特异性
CD320 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011],
组织表达
Detected in the germinal center (GC) of lymphoid follicles (at protein level) (PubMed:11418631). Expressed abundantly on follicular dendritic cells (FDCs) (PubMed:10727470).
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
function:Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.,similarity:Contains 2 LDL-receptor class A domains.,tissue specificity:Expressed abundantly on follicular dendritic cells (FDCs).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
