产品名称
TCPR2 Rabbit Polyclonal Antibody
基因名称
TECPR2 KIAA0297 KIAA0329
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9895
Human Swissprot No.
O15040
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15040/entry
免疫原
Synthesized peptide derived from human TCPR2 AA range: 598-648
特异性
This antibody detects endogenous levels of TCPR2 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy, as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR), which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015],
组织表达
Detected in skin fibroblast (at protein level).
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
