产品名称
LOX15 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/246
Human Swissprot No.
P16050
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P16050/entry
免疫原
Synthesized peptide derived from human LOX15 AA range: 156-206
特异性
This antibody detects endogenous levels of LOX15 at Human
宿主
Polyclonal, Rabbit,IgG
组织表达
Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.
细胞定位
Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein . Lipid droplet . Predominantly cytosolic; becomes enriched at membranes upon calcium binding (By similarity). Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells (By similarity). .
功能
catalytic activity:Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.,cofactor:Binds 1 iron ion per subunit.,function:Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid.,pathway:Lipid metabolism; leukotriene D4 biosynthesis.,similarity:Belongs to the lipoxygenase family.,similarity:Contains 1 lipoxygenase domain.,similarity:Contains 1 PLAT domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
