产品名称
HSF2B Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11077
Human Swissprot No.
O75031
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75031/entry
免疫原
Synthesized peptide derived from human HSF2B AA range: 201-251
特异性
This antibody detects endogenous levels of HSF2B at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008],
组织表达
Testis specific. Overexpressed in some tumors (PubMed:31242413).
细胞定位
Cytoplasm . Chromosome . Localizes on double-strand breaks (DSBs) in mitotic and meiotic chromosomes. .
功能
function:May be involved in modulating HSF2 activation in testis.,PTM:Sumoylated by UBE2I in response to MEKK1-mediated stimuli.,subunit:Associates with HSF2. The interaction seems to occur between the trimerization domain of HSF2 and the N-terminal hydrophilic region of HSF2BP.,tissue specificity:Testis specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
