产品名称
FACR2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55711
Human Swissprot No.
Q96K12
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96K12/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/330450
Mouse Swissprot No.
Q7TNT2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TNT2
免疫原
Synthesized peptide derived from human FACR2 AA range: 409-459
特异性
This antibody detects endogenous levels of FACR2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012],
细胞定位
Peroxisome membrane ; Single-pass membrane protein .
功能
catalytic activity:Fatty acyl-CoA + 2 NADPH = fatty alcohol + 2 NADP(+).,function:Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates.,similarity:Belongs to the fatty acyl-CoA reductase family.,subcellular location:Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
