产品名称
MPZL1 Rabbit Polyclonal Antibody
基因名称
MPZL1 PZR UNQ849/PRO1787
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9019
Human Swissprot No.
O95297
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95297/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/68481
Mouse Swissprot No.
Q3TEW6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TEW6
Rat Gene Link
https://www.uniprot.org/uniprot/360871
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AYT8
免疫原
Synthesized peptide derived from human MPZL1 AA range: 179-229
特异性
This antibody detects endogenous levels of MPZL1 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
组织表达
Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.
细胞定位
Membrane ; Single-pass type I membrane protein .
功能
domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.,PTM:N-glycosylated.,PTM:Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin A (ConA). Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro).,similarity:Belongs to the myelin P0 protein family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with phosphorylated PTPN11/SHP-2.,tissue specificity:Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hemotopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbelical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
