产品名称
CO9A2 Rabbit Polyclonal Antibody
蛋白名称
Collagen alpha-2(IX) chain
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14055
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14055/entry
Mouse Swissprot No.
Q07643
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q07643
免疫原
Synthesized peptide derived from human protein . at AA range: 540-620
特异性
CO9A2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. This chain is unusual in that, unlike the other two type IX alpha chains, it contains a covalently attached glycosaminoglycan side chain. Mutations in this gene are associated with multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008],
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
disease:Defects in COL9A2 are the cause of multiple epiphyseal dysplasia type 2 (EDM2) [MIM:600204]. EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM2 inheritance is autosomal dominant.,disease:Defects in COL9A2 may be a cause of susceptibility to intervertebral disc disease (IDD) [MIM:603932]. IDD is one of the most common musculo-skeletal disorders.,function:Structural component of hyaline cartilage and vitreous of the eye.,PTM:Covalently linked to the telopeptides of type II collagen by lysine-derived cross-links.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,similarity:Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.,subunit:Heterotrimer of an alpha 1(IX), an alpha 2(IX) and an alpha 3(IX) chain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
