产品名称
FXL18 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/80028
Human Swissprot No.
Q96ME1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96ME1/entry
免疫原
Synthesized peptide derived from human FXL18 AA range: 7-57
特异性
This antibody detects endogenous levels of FXL18 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016],
功能
function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 3 LRR (leucine-rich) repeats.,subunit:Directly interacts with SKP1A and CUL1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
