产品名称
SARDH Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1757
Human Swissprot No.
Q9UL12
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UL12/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/192166
Mouse Swissprot No.
Q99LB7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99LB7
Rat Gene Link
https://www.uniprot.org/uniprot/114123
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q64380
免疫原
Synthesized peptide derived from human SARDH AA range: 279-329
特异性
This antibody detects endogenous levels of SARDH at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2008],
组织表达
Expressed in pancreas, liver and kidney.
细胞定位
Mitochondrion matrix .
功能
catalytic activity:Sarcosine + acceptor + H(2)O = glycine + formaldehyde + reduced acceptor.,cofactor:Binds 1 FAD covalently per monomer.,disease:Defects in SARDH are a ause of sarcosinemia [MIM:268900]. Sarcosinemia is a metabolic disorder characterized by an increased concentration of sarcosine in plasma and urine due to sarcosine dehydrogenase deficiency. Prevalence has been estimated at 1:28'000 to 1:350'000 in newborn screening programs. Sarcosinemia is most probably a benign condition without significant clinical problems. It is transmitted in an autosomal recessive manner.,pathway:Amine and polyamine degradation; sarcosine degradation; formaldehyde and glycine from sarcosine: step 1/1.,similarity:Belongs to the gcvT family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
