产品名称
AP3M2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10947
Human Swissprot No.
P53677
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P53677/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/64933
Mouse Swissprot No.
Q8R2R9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R2R9
Rat Gene Link
https://www.uniprot.org/uniprot/140667
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P53678
免疫原
Synthesized peptide derived from human AP3M2 AA range: 274-324
特异性
This antibody detects endogenous levels of AP3M2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008],
细胞定位
Golgi apparatus. Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. .
功能
function:Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.,similarity:Belongs to the adaptor complexes medium subunit family.,similarity:Contains 1 MHD (mu homology) domain.,subunit:Adaptor protein complex 3 (AP-3) is an heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
