产品名称
SAP18 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10284
Human Swissprot No.
O00422
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00422/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20220
Mouse Swissprot No.
O55128
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O55128
免疫原
Synthesized peptide derived from human SAP18
特异性
This antibody detects endogenous levels of SAP18 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008],
细胞定位
Nucleus . Cytoplasm . Nucleus speckle . Shuttles between the nucleus and the cytoplasm (PubMed:16314458). Colocalizes with ACIN1 and SRSF2 in nuclear speckles (PubMed:20966198). .
功能
function:Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins.,similarity:Belongs to the SAP18 family.,subunit:Forms a complex with SIN3A and HDAC1.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
