产品名称
FHOD1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/29109
Human Swissprot No.
Q9Y613
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y613/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/234686
Mouse Swissprot No.
Q6P9Q4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P9Q4
免疫原
Synthesized peptide derived from human FHOD1 AA range: 210-260
特异性
This antibody detects endogenous levels of FHOD1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
组织表达
Ubiquitous. Highly expressed in spleen.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Predominantly cytoplasmic.
功能
domain:Regulated by intramolecular binding to a C-terminal auto-inhibitory domain. Effector binding abolishes this interaction and activates the protein.,function:Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.,similarity:Belongs to the formin homology family.,similarity:Contains 1 FH1 (formin homology 1) domain.,similarity:Contains 1 FH2 (formin homology 2) domain.,similarity:Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.,subcellular location:Predominantly cytoplasmic.,subunit:Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus.,tissue specificity:Ubiquitous. Highly expressed in spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
