产品名称
TMPS2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7113
Human Swissprot No.
O15393
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15393/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/50528
Mouse Swissprot No.
Q9JIQ8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JIQ8
免疫原
Synthesized peptide derived from human TMPS2 AA range: 98-148
特异性
This antibody detects endogenous levels of TMPS2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008],
组织表达
Expressed in several tissues that comprise large populations of epithelial cells with the highest level of transcripts measured in the prostate gland. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland. Coexpressed with ACE2 within lung type II pneumocytes, ileal absorptive enterocytes, intestinal epithelial cells, cornea, gallbladder and nasal goblet secretory cells (Ref.21).
细胞定位
Cell membrane ; Single-pass type II membrane protein .; [Transmembrane protease serine 2 catalytic chain]: Secreted . Activated by cleavage and secreted. .
功能
similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 SRCR domain.,subcellular location:Activated by cleavage and secreted.,tissue specificity:Expressed strongly in small intestine. Also expressed in prostate, colon, stomach and salivary gland.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
