产品名称
ACTY Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10120
Human Swissprot No.
P42025
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P42025/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/226977
Mouse Swissprot No.
Q8R5C5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R5C5
免疫原
Synthesized peptide derived from human ACTY AA range: 29-79
特异性
This antibody detects endogenous levels of ACTY at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008],
细胞定位
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
功能
function:Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.,similarity:Belongs to the actin family.,similarity:Belongs to the actin family. ARP1 subfamily.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
