产品名称
NYX Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/60506
Human Swissprot No.
Q9GZU5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9GZU5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/236690
Mouse Swissprot No.
P83503
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P83503
免疫原
Synthesized peptide derived from human NYX AA range: 139-189
特异性
This antibody detects endogenous levels of NYX at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq, Oct 2008],
组织表达
Expressed in kidney and retina. Also at low levels in brain, testis and muscle. Within the retina, expressed in the inner segment of photoreceptors, outer and inner nuclear layers and the ganglion cell layer.
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
disease:Defects in NYX are the cause of congenital stationary night blindness type 1A (CSNB1A) [MIM:310500]; also called X-linked congenital stationary night blindness (XLCSNB). Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNB1A is characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class IV subfamily.,similarity:Contains 11 LRR (leucine-rich) repeats.,tissue specificity:Expressed in kidney and retina. Also at low levels in brain, testis and muscle. Within the retina, expressed in the inner segment of photoreceptors, outer and inner nuclear layers and the ganglion cell layer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
