产品名称
PUR6 Rabbit Polyclonal Antibody
基因名称
PAICS ADE2 AIRC PAIS
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10606
Human Swissprot No.
P22234
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P22234/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67054
Mouse Swissprot No.
Q9DCL9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DCL9
Rat Gene Link
https://www.uniprot.org/uniprot/140946
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P51583
免疫原
Synthesized peptide derived from human PUR6 AA range: 107-157
特异性
This antibody detects endogenous levels of PUR6 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
cytoplasm,cytosol,cell-cell adherens junction,membrane,extracellular exosome,
功能
catalytic activity:5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).,catalytic activity:ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.,pathway:Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 3/5.,pathway:Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5.,similarity:In the C-terminal section; belongs to the AIR carboxylase family.,similarity:In the N-terminal section; belongs to the SAICAR synthetase family.,subunit:Homooctamer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
