产品名称
SPP2A Rabbit Polyclonal Antibody
基因名称
SPPL2A IMP3 PSL2 PSEC0147
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84888
Human Swissprot No.
Q8TCT8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TCT8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/66552
Mouse Swissprot No.
Q9JJF9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJF9
免疫原
Synthesized peptide derived from human SPP2A AA range: 66-116
特异性
This antibody detects endogenous levels of SPP2A at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012],
细胞定位
Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein ; Lumenal side . Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.
功能
function:Functions as an intramembrane protease. Functions in ITM2B processing.,similarity:Belongs to the peptidase A22B family.,similarity:Contains 1 PA (protease associated) domain.,subunit:Interacts with ITM2B.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
