产品名称
PP12C Rabbit Polyclonal Antibody
基因名称
PPP1R12C LENG3 MBS85
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54776
Human Swissprot No.
Q9BZL4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BZL4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/232807
Mouse Swissprot No.
Q3UMT1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UMT1
免疫原
Synthesized peptide derived from human PP12C AA range: 542-592
特异性
This antibody detects endogenous levels of PP12C at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012],
组织表达
Ubiquitously expressed. Highly expressed in heart.
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, stress fiber .
功能
caution:Although assigned as two separate genes (PPP1R12C and LENG3), it is probable that LENG3 does not exist by itself and is a part of the PPP1R12C gene.,function:Regulates myosin phosphatase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Unspliced mRNA.,similarity:Contains 4 ANK repeats.,subcellular location:Along actomyosin filaments and stress fibers.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP.,tissue specificity:Ubiquitously expressed. Highly expressed in heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
