产品名称
RNF6 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase RNF6 (EC 6.3.2.-)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y252
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y252/entry
Mouse Swissprot No.
Q9DBU5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DBU5
免疫原
Synthesized peptide derived from human protein . at AA range: 470-550
特异性
RNF6 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008],
组织表达
Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
细胞定位
Nucleus . Cytoplasm . Cell projection, axon . Nucleus, PML body . Localizes to the PML nuclear bodies in Sertoli cells. .
功能
similarity:Contains 1 RING-type zinc finger.,tissue specificity:Weakly expressed in peripheral blood, spleen, prostate, testis and ovary.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
