产品名称
FBX22 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/26263
Human Swissprot No.
Q8NEZ5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NEZ5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/71999
Mouse Swissprot No.
Q78JE5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q78JE5
免疫原
Synthesized peptide derived from human FBX22 AA range: 182-232
特异性
This antibody detects endogenous levels of FBX22 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010],
组织表达
Predominantly expressed in liver, also enriched in cardiac muscle.
细胞定位
Cytoplasm, myofibril, sarcomere, Z line .
功能
function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,subunit:Directly interacts with SKP1A and CUL1.,tissue specificity:Predominantly expressed in liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
