产品名称
GPAT4 Rabbit Polyclonal Antibody
基因名称
AGPAT6 GPAT4 UNQ551/PRO1108
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/137964
Human Swissprot No.
Q86UL3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86UL3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/102247
Mouse Swissprot No.
Q8K2C8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K2C8
免疫原
Synthesized peptide derived from human GPAT4 AA range: 39-89
特异性
This antibody detects endogenous levels of GPAT4 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004],
组织表达
Ubiquitous. High levels in testis. Relatively high level of expression in skeletal muscle and heart. Relatively low level of expression in lung.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
catalytic activity:Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.,domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,enzyme regulation:Inhibited by N-ethylmaleimide (NEM).,function:Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.,pathway:Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.,similarity:Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.,tissue specificity:Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
