产品名称
NOSTN Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/115677
Human Swissprot No.
Q8IVI9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IVI9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/329416
Mouse Swissprot No.
Q6WKZ7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6WKZ7
Rat Gene Link
https://www.uniprot.org/uniprot/311111
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5I0D6
免疫原
Synthesized peptide derived from human NOSTN AA range: 309-359
特异性
This antibody detects endogenous levels of NOSTN at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004],
组织表达
Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).
细胞定位
[Isoform 1]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle . Cytoplasm, cytoskeleton . Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).; [Isoform 3]: Nucleus .
功能
domain:The FCH domain is necessary for membrane targeting.,domain:The SH3 domain mediates interaction with NOS3, DNM2 and WASL.,function:Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.,similarity:Contains 1 FCH domain.,similarity:Contains 1 SH3 domain.,subcellular location:Enriched in selected actin structures.,subunit:Homotrimer. Interacts with DAB2 (By similarity). Interacts with NOS3, DNM2, WASL and CAV1.,tissue specificity:Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
