产品名称
AP4B1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10717
Human Swissprot No.
Q9Y6B7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y6B7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67489
Mouse Swissprot No.
Q9WV76
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WV76
免疫原
Synthesized peptide derived from human AP4B1 AA range: 595-645
特异性
This antibody detects endogenous levels of AP4B1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
细胞定位
Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein .
功能
function:Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.,similarity:Belongs to the adaptor complexes large subunit family.,subcellular location:Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.,subunit:Adapter-like complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1).,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
