产品名称
ADCY5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/111
Human Swissprot No.
O95622
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95622/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/224129
Mouse Swissprot No.
P84309
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P84309
Rat Gene Link
https://www.uniprot.org/uniprot/64532
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q04400
免疫原
Synthesized peptide derived from human ADCY5 AA range: 471-521
特异性
This antibody detects endogenous levels of ADCY5 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
组织表达
Detected in pancreas islets (at protein level). Detected in pancreas islets.
细胞定位
Cell membrane ; Multi-pass membrane protein. Cell projection, cilium .
功能
catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Inhibition by calcium in the submicromolar concentration range.,function:This is a membrane-bound, calcium-inhibitable adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
